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PEARL-SC

 

Study Summary:

The primary objective of this study is to evaluate the long-term safety of A-623 in subjects with SLE.

 

For latest updates please go to clinicaltrials.gov

 

Status:

Completed

 

Publications:

Buyon JP, Petri MA, Kim MY, Kalunian KC, Grossman J, Hahn BH, et. al. The effect of combined estrogen and progesterone hormone replacement therapy on disease activity in systemic lupus erythematosus: a randomized trial. Ann Intern Med. 2005;142:953–62.
doi:10.7326/0003-4819-142-12 Part 1-200506210-00004

Cella D, Yount S, Sorensen M, Chartash E, Sengupta N, and Grober J. Validation of the functional assessment of chronic illness therapy fatigue scale relative to other instrumentation in patients with rheumatoid arthritis. J Rheumatol. 2005;32:811–19.
doi: 10.1136/ard.2006.065763

Danchenko N, Satia JA, and Anthony MS. Epidemiology of systemic lupus erythematosus: a comparison of worldwide disease burden. Lupus. 2006;15:308–18.
doi: 10.1191/0961203306lu2305xx

Ferbas J, Wallace DJ, Weisman MH, et al. A Systematic Analysis of Circulating B cell Populations in Healthy and SLE Subjects. SAT 0443, EULAR 2006 (2006).

Khare, SD, Sarosi, I, Xia XZ, McCabe S, Miner K, Solovyev I, et al. Severe B cell hyperplasia and autoimmune disease in TALL-1 transgenic mice. Proc Natl Acad Sci USA. 2000;97:3370–75.
doi/10.1073/pnas.050580697

Kotzin BL. Systemic lupus erythematosus. Cell. 1996;85:303–06.

Lim SS and Drenkard C. Epidemiology of systemic lupus erythematosus: capturing the butterfly. Curr Rheumatol Rep. 2008;10(4):265–72.
doi: 10.1007/s11926-008-0043-4

Petri M, Kim MY, Kalunian KC, Grossman J, Hahn BH, Sammaritano LR, et al. Combined oral contraceptives in women with systemic lupus erythematosus. N Engl J Med. 2005;353(24):2550–58.
doi: 10.1056/NEJMoa051135

Petri M, Stohl W, Chatham W, McCune WJ, Chevrier M, Ryel J, et al. Association of plasma B lymphocyte stimulator levels and disease activity in systemic lupus erythematosus. Arthritis Rheum. 2008;58(8):2453–59.
doi: 10.1002/art.23678.

Siegel M and Lee SL. The epidemiology of systemic lupus erythematosus. Semin Arthritis Rheum. 1973;3:1–54.
http://dx.doi.org/10.1016/0049-0172(73)90034-6

 

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