sPLA2 - What is it?
Secretary phospholipase 
(
) is a calcium dependent enzyme which cleaves phospholipids at the sn-2 position to generate non-esterified fatty acids and lysophospholipids (LPL). is secreted by many cells within the body and is induced by inflammatory signals such as tumor necrosis factor (TNF) and interleukin-1 (IL-1) [1].
There are 10 known enzymes in the family of which group IIA is considered the prototypic inflammatory isoform. It has been implicated in a number of inflammatory diseases and tissue injury. By generating important intermediates such as arachidonic acid or lysoplatelet activating factor (Lyso-PAF), may play an important role as a mediator in the process of inflammation.]
Role of in the generation of arachidonic acid and other mediators of inflammation.